God opposes the proud, but gives grace to the humble. This seems to be a core tenet at the center of understanding everything.
If you are enamored of your own self-sufficiency, awed by your own autonomy, then remember that thereby do you make God your enemy. He will work against you in your arrogant ways.
Conversely, if you work hard to keep a balanced, full, and rich understanding of your complete nature, remembering the image of God woven through your entire being and your desperately broken, fallen, sinful nature, this is humility. And by it, God becomes your supporter and friend, giving you grace, strength, and wisdom.